Coagulation disorders like antiphospholipid syndrome and DIC.
Cardiac valve replacement or coronary angioplasty.
Ischemic stroke, transient ischemic attack.
Deep vein thrombosis, pulmonary embolism.
Causes an initial period of hypercoagulation (due to protein C depletion) followed by anticoagulation.
Inhibits maturation of clotting factors II, VII, IX, X and anti-coagulation proteins C, S.
Blocks vitamin K epoxide reductase and prevent regeneration of vitamin K epoxide, which is a cofactor for the enzyme gamma-glutamyl carboxylase, which converts the non-functional forms of coagulation factors II, VII, IX, and X and anticoagulation proteins C and S, into their functional forms.
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